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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Stockholm University, Faculty of Science, Numerical Analysis and Computer Science (NADA). Karolinska Institutet, Sweden; Karolinska Universitetsjukhuset, Sweden.
Number of Authors: 304
2017 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 49, no 3, 403-415 p.Article in journal (Refereed) Published
Abstract [en]

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.

Place, publisher, year, edition, pages
2017. Vol. 49, no 3, 403-415 p.
National Category
Medical Genetics Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-141217DOI: 10.1038/ng.3768ISI: 000394917800014PubMedID: 28135244OAI: oai:DiVA.org:su-141217DiVA: diva2:1089559
Available from: 2017-04-20 Created: 2017-04-20 Last updated: 2017-04-20Bibliographically approved

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