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Lifetime Modulation of the Pain System via Neuroimmune and Neuroendocrine interactions
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Number of Authors: 2
2017 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 8, 276Article, review/survey (Refereed) Published
Abstract [en]

Chronic pain is a debilitating condition that still is challenging both clinicians and researchers. Despite intense research, it is still not clear why some individuals develop chronic pain while others do not or how to heal this disease. In this review, we argue for a multisystem approach to understand chronic pain. Pain is not only to be viewed simply as a result of aberrant neuronal activity but also as a result of adverse early-life experiences that impact an individual's endocrine, immune, and nervous systems and changes which in turn program the pain system. First, we give an overview of the ontogeny of the central nervous system, endocrine, and immune systems and their windows of vulnerability. Thereafter, we summarize human and animal findings from our laboratories and others that point to an important role of the endocrine and immune systems in modulating pain sensitivity. Taking early-life history into account, together with the past and current immunological and endocrine status of chronic pain patients, is a necessary step to understand chronic pain pathophysiology and assist clinicians in tailoring the best therapeutic approach.

Place, publisher, year, edition, pages
2017. Vol. 8, 276
Keyword [en]
psychoneuroimmunology, lipopolysaccharide, inflammation, pain, neuroimmunology, neuroendocrinology, hypothalamo-pituitary-adrenal axis, stress
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:su:diva-142668DOI: 10.3389/fimmu.2017.00276ISI: 000396206400001PubMedID: 28348566OAI: oai:DiVA.org:su-142668DiVA: diva2:1094808
Available from: 2017-05-11 Created: 2017-05-11 Last updated: 2017-05-11Bibliographically approved

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