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Design of a Pd(0)-CalB CLEA Biohybrid Catalyst and Its Application in a One-Pot Cascade Reaction
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
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Number of Authors: 8
2017 (English)In: ACS Catalysis, ISSN 2155-5435, E-ISSN 2155-5435, Vol. 7, no 3, 1601-1605 p.Article in journal (Refereed) Published
Abstract [en]

Herein, a design of a biohybrid catalyst is described, consisting of Pd nanoparticles and a cross-linked network of aggregated lipase B enzyme of Candida antarctica (CalB CLEA) functioning as an active support for the Pd nanoparticles. Both entities of the hybrid catalyst showed good catalytic activity. The applicability was demonstrated in a one-pot reaction, where the Pd-catalyzed cycloisomerization of 4-pentynoic acid afforded a lactone that serves as an acyl donor in a subsequent selective enzymatic kinetic resolution of a set of sec-alcohols. The catalyst proved to be robust and could be recycled five times without a significant loss of activity.

Place, publisher, year, edition, pages
2017. Vol. 7, no 3, 1601-1605 p.
Keyword [en]
kinetic resolution, biohybrid catalyst, Pd nanoparticles, CalB, cycloisomerization, one-pot cascade reaction
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-142484DOI: 10.1021/acscatal.6b03481ISI: 000395726500011OAI: oai:DiVA.org:su-142484DiVA: diva2:1096022
Available from: 2017-05-16 Created: 2017-05-16 Last updated: 2017-05-16Bibliographically approved

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Görbe, TamásGustafson, Karl P. J.Kervefors, GabriellaZou, XiaodongJohnston, Eric V.Bäckvall, Jan-E.
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