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Longitudinal association between hippocampus atrophy and episodic-memory decline
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Number of Authors: 82017 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 51, p. 167-176Article in journal (Refereed) Published
Abstract [en]

There is marked variability in both onset and rate of episodic-memory decline in aging. Structural magnetic resonance imaging studies have revealed that the extent of age-related brain changes varies markedly across individuals. Past studies of whether regional atrophy accounts for episodic-memory decline in aging have yielded inconclusive findings. Here we related 15-year changes in episodic memory to 4-year changes in cortical and subcortical gray matter volume and in white-matter connectivity and lesions. In addition, changes in word fluency, fluid IQ (Block Design), and processing speed were estimated and related to structural brain changes. Significant negative change over time was observed for all cognitive and brain measures. A robust brain-cognition change-change association was observed for episodic-memory decline and atrophy in the hippocampus. This association was significant for older (65-80 years) but not middle-aged (55-60 years) participants and not sensitive to the assumption of ignorable attrition. Thus, these longitudinal findings highlight medial-temporal lobe system integrity as particularly crucial for maintaining episodic-memory functioning in older age.

Place, publisher, year, edition, pages
2017. Vol. 51, p. 167-176
Keywords [en]
Aging, Cognitive decline, Episodic memory, Hippocampus, Longitudinal changes, Nonignorable attrition
National Category
Geriatrics Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-142451DOI: 10.1016/j.neurobiolaging.2016.12.002ISI: 000397168600018PubMedID: 28089351OAI: oai:DiVA.org:su-142451DiVA, id: diva2:1096747
Available from: 2017-05-19 Created: 2017-05-19 Last updated: 2018-01-13Bibliographically approved

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