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Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Number of Authors: 3
2017 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 52, 81-89 p.Article in journal (Refereed) Published
Abstract [en]

Recent studies have reported several genetic, health, and aging interaction effects in predicting cognitive performance and change. We used an accelerated longitudinal design to examine interactions among genetic, lifestyle, and aging for executive function (EF) in non-demented older adults (n = 634; age range = 53-95 years). The polymorphisms were apolipoprotein E (APOE), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF). We tested (1) independent and additive effects of APOE, COMT, and BDNF and (2) APOE effect modification for COMT + BDNF, on EF performance and 9-year change as separated by age and lifestyle activities. First, APOE epsilon 4+ carriers had poorer EF performance and steeper 9-year decline. Second, APOE epsilon 4+ carriers with (1) BDNF Met/Met genotype and (2) increasing allelic risk in the COMT + BDNF risk panel had poorer EF performance; these effects were moderated by lifestyle activities (composite of everyday social, physical, and cognitive activities). Examining APOE effect modification for COMT + BDNF risk panel effects with other moderating factors may help identify complex neurobiological and genetic underpinnings of polygenic phenotypes such as EF in aging.

Place, publisher, year, edition, pages
2017. Vol. 52, 81-89 p.
Keyword [en]
Aging, Executive function, Apolipoprotein E, Catechol-O-methyltransferase, Brain-derived neurotrophic factor, Victoria Longitudinal Study
National Category
Geriatrics Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-142612DOI: 10.1016/j.neurobiolaging.2016.12.022ISI: 000397169000009PubMedID: 28131014OAI: oai:DiVA.org:su-142612DiVA: diva2:1097208
Available from: 2017-05-22 Created: 2017-05-22 Last updated: 2017-05-22Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf