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Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Catholic University of Rome, Italy.
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Number of Authors: 11
2017 (English)In: The Journal of Clinical Hypertension, ISSN 1524-6175, E-ISSN 1751-7176, Vol. 19, no 4, 418-423 p.Article in journal (Refereed) Published
Abstract [en]

The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4 +/- 7.6years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.

Place, publisher, year, edition, pages
2017. Vol. 19, no 4, 418-423 p.
Keyword [en]
ambulatory blood pressure monitoring, dysautonomia, hypertension, non-motor symptoms, Parkinsons disease
National Category
Neurology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:su:diva-142603DOI: 10.1111/jch.12938ISI: 000398857700014PubMedID: 27804276OAI: oai:DiVA.org:su-142603DiVA: diva2:1097988
Available from: 2017-05-23 Created: 2017-05-23 Last updated: 2017-05-23Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
More styles
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  • de-DE
  • en-GB
  • en-US
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  • nn-NO
  • nn-NB
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  • Other locale
More languages
Output format
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