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Associations between systemic pro-inflammatory markers, cognitive function and cognitive complaints in a population-based sample of working adults
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). University of Chicago, USA.
Stockholm University, Faculty of Social Sciences, Stress Research Institute.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institute, Sweden.
Number of Authors: 4
2017 (English)In: Journal of Psychosomatic Research, ISSN 0022-3999, E-ISSN 1879-1360, Vol. 96, 49-59 p.Article in journal (Refereed) Published
Abstract [en]

Background: The knowledge is limited regarding the relation between systemic inflammatory biomarkers and subjective and objective cognitive functioning in population-based samples of healthy adults across the adult age-span. Thus, the aim of this study was to study a selection of four pro-inflammatory biomarkers (IL-6, MCP-1, TNF-alpha, CRP) in relation to executive cognitive functioning, episodic memory and subjective cognitive complaints (SCC) in a population-based sample of 215 working adults (age 25-67).

Results: Higher levels of MCP-1 were associated with poorer executive cognitive functioning, even after adjustments for demographical factors, health status/conditions, SCC and depressive symptoms. IL-6 and CRP were associated with poorer executive cognitive functioning, but these associations covaried with age especially and were not present after adjustment for demographical factors. MCP-1 was associated with poorer episodic memory, but this association also covaried with age especially and was not present after adjustment for demographical factors, and CRP was associated with episodic memory only among participants without reported health conditions. Higher MCP-1 levels were also associated with more SCC and this association covaried with depressive symptoms, while higher levels of TNF-alpha were associated with less SCC.

Conclusion: Low grade inflammatory processes in terms of higher systemic levels of pro-inflammatory biomarkers (MCP-1, IL-6 & CRP) were associated with poorer executive functioning in this sample of working adults, and MCP-1 was so after extensive adjustments. Support for associations between these biomarkers and episodic memory and SCC were more limited. Future research should address the causality of associations between low grade inflammatory processes and cognitive functioning.

Place, publisher, year, edition, pages
2017. Vol. 96, 49-59 p.
Keyword [en]
Inflammatory markers, Cytokines: cognition: executive cognitive functioning, Episodic memory, Subjective cognitive complaints, Working adults, Population-based
National Category
Psychiatry Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:su:diva-144855DOI: 10.1016/j.jpsychores.2017.03.010ISI: 000402852500009PubMedID: 28545793OAI: oai:DiVA.org:su-144855DiVA: diva2:1118464
Available from: 2017-06-30 Created: 2017-06-30 Last updated: 2017-06-30Bibliographically approved

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