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N-Trifluoromethylation of Nitrosoarenes with Sodium Triflinate
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0001-6517-8879
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0002-7826-9953
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0002-7826-9953
2017 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 19, no 9, 2374-2377 p.Article in journal, Letter (Refereed) Published
Abstract [en]

A highly efficient N-trifluoromethylation of nitro-soarenes is reported. The inexpensive and convenient Langlois reagent (sodium triflinate) is employed as a Ch(3)-radical source in combination with a copper catalyst and an oxidant. N-Trifluoromethylated hychoxylamines are obtained in high yields within 1 h at room temperature. The addition of hydroquinone was found to be instrumental to prevent the formation of side products. The method is high-yielding is scalable, and displays a high functional group tolerance.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 19, no 9, 2374-2377 p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-144846DOI: 10.1021/acs.orglett.7b00908ISI: 000401044500045PubMedID: 28402669OAI: oai:DiVA.org:su-144846DiVA: diva2:1119402
Funder
Swedish Research Council
Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-10-03Bibliographically approved

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van der Werf, AngelaHribersek, MaticSelander, Nicklas
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