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On-line extraction and determination of residual sulfathiazole in pharmaceutical wastewater with molecularly imprinted polymers in a packed cartridge coupled with high-performance liquid chromatography
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Number of Authors: 4
2017 (English)In: Analytical Methods, ISSN 1759-9660, E-ISSN 1759-9679, Vol. 9, no 20, 3019-3028 p.Article in journal (Refereed) Published
Abstract [en]

A new, rapid and sensitive on-line extraction and determination technique was developed with molecularly imprinted polymers (MIPs) in a packed cartridge. An artificial selective polymeric sorbents packed in a polyethylene cartridge were employed for the separation of sulfathiazole residue. The packing particles were synthesized using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker agent, sulfathiazole as a target template molecule and azobisisobutyronitrile as an initiator. The optimal conditions for designing these sorbents were as follows: conditioning using water with pH = 3.0, loading the sample under mild basic aqueous conditions, cleanup using 2 x 2 mL acetonitrile and elution with 3.0 mL 20 mM ammonium acetate : acetonitrile (75 : 25 v/v, pH = 3.0). In this system, an aliquot of extracted template was injected to the HPLC analytical column with acetonitrile : water (75 : 25 v/v) and water (pH adjusted to 3.0 with H3PO4) as the mobile phases in a gradient elution program. The selectivity of the MIPs in the packed cartridge was evaluated by checking several substances with molecular structures similar to that of the template. The results revealed a recovery of more than 92% along with a limit of detection and limit of quantification of 0.05 and 0.16 ng mL(-1), respectively, for the on-line determination of sulfathiazole in pharmaceutical wastewater samples.

Place, publisher, year, edition, pages
2017. Vol. 9, no 20, 3019-3028 p.
National Category
Chemical Sciences Other Agricultural Sciences Other Engineering and Technologies
Identifiers
URN: urn:nbn:se:su:diva-144811DOI: 10.1039/c7ay00131bISI: 000402044500012OAI: oai:DiVA.org:su-144811DiVA: diva2:1121588
Available from: 2017-07-12 Created: 2017-07-12 Last updated: 2017-07-12Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf