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Effects of Hydroxylated Polybrominated Diphenyl Ethers in Developing Zebrafish Are Indicative of Disruption of Oxidative Phosphorylation
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. Swedish University of Agricultural Sciences, Sweden.
Number of Authors: 4
2017 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 18, no 5, 970Article in journal (Refereed) Published
Abstract [en]

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have been detected in humans and wildlife. Using in vitro models, we recently showed that OH-PBDEs disrupt oxidative phosphorylation (OXPHOS), an essential process in energy metabolism. The goal of the current study was to determine the in vivo effects of OH-PBDE reported in marine wildlife. To this end, we exposed zebrafish larvae to 17 OH-PBDEs from fertilisation to 6 days of age, and determined developmental toxicity as well as OXPHOS disruption potential with a newly developed assay of oxygen consumption in living embryos. We show here that all OH-PBDEs tested, both individually and as mixtures, resulted in a concentration-dependant delay in development in zebrafish embryos. The most potent substances were 6'-OH-BDE47 and 6-OH-BDE49 (No-Effect-Concentration: 0.1 and 0.05 mu M). The first 24 h of development were the most sensitive, resulting in significant and irreversible developmental delay. All substances increased oxygen consumption, an effect indicative of OXPHOS disruption. Our results suggest that the induced developmental delay may be caused by disruption of OXPHOS. Though further studies are needed, our findings suggest that the environmental concentrations of some OH-PBDEs found in Baltic Sea wildlife in the Baltic Sea may be of toxicological concern.

Place, publisher, year, edition, pages
2017. Vol. 18, no 5, 970
Keyword [en]
zebrafish, OXPHOS disruption, hydroxylated PBDEs
National Category
Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-145268DOI: 10.3390/ijms18050970ISI: 000404113900077OAI: oai:DiVA.org:su-145268DiVA: diva2:1128524
Available from: 2017-07-26 Created: 2017-07-26 Last updated: 2017-07-26Bibliographically approved

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CiteExportLink to record
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