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Intrinsic brain connectivity after partial sleep deprivation in young and older adults
Karolinska Institutet, Sweden.
Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute.
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2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Introduction: Sleep deprivation has been reported to affect intrinsic brain connectivity, notably in the default mode network, but studies to date have shown inconsistent effects and have largely included young participants. We therefore aimed to investigate effects of partial sleep deprivation on intrinsic brain connectivity in young and older participants. Methods: Participants aged 20-30 (n = 30) and 65-75 (n = 23) years underwent partial sleep deprivation (3 h sleep) in a cross-over design, with two eyes-open resting state functional magnetic resonance imaging (fMRI) runs in each session. We assessed intrinsic brain connectivity using independent components analysis (ICA) as well as seed-region analyses of functional connectivity, and also analysed global signal variability, regional homogeneity, and the amplitude of low-frequency fluctuations. Participants were monitored with eye-tracking to ensure they did not fall asleep during scanning. Results: Sleep deprivation caused increased global signal variability, defined as log-transformed standard deviation of average gray matter signal (0.16 [0.07, 0.24], p = 0.0004). In contrast to previous studies, sleep deprivation did not cause major changes in investigated resting state networks, nor did it cause changes in regional homogeneity. Younger participants had higher functional connectivity in most examined resting state networks, as well as higher regional homogeneity in brain areas including anterior and posterior cingulate cortex. Conclusions: We show for the first time that partial sleep deprivation caused increased global signal variability. This outcome should be examined as a potential biomarker for sleepiness using independent data. Unlike a few earlier studies, we did not find less default mode connectivity in the sleep deprived state, possibly because of stricter monitoring of participants' wakefulness.

Place, publisher, year, edition, pages
2017. article id 1909
Keywords [en]
Aging, sleep
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-145534OAI: oai:DiVA.org:su-145534DiVA, id: diva2:1130067
Conference
23rd Annual Meeting of the Organization for Human Brain Mapping, Vancouver, Canada, June 25-29, 2017
Available from: 2017-08-08 Created: 2017-08-08 Last updated: 2017-12-01Bibliographically approved

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Nilsonne, GustavTamm, SandraSchwarz, JohannaFischer, HåkanKecklund, GöranLekander, MatsÅkerstedt, Torbjörn
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CiteExportLink to record
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Citation style
  • apa
  • ieee
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