EnglishSvenskaNorsk
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Show others and affiliations
Number of Authors: 122017 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1464-3405, Vol. 27, no 15, p. 3219-3225Article in journal (Refereed) Published
Abstract [en]

Two screening campaigns using commercial (Chembridge DiverSET) and proprietary (Chemical Biology Consortium Sweden, CBCS) compound libraries, revealed a number of pyridone- and pyrimidinone-derived systems as inhibitors of the human dCTP pyrophosphatase 1 (dCTPase). In this letter, we present their preliminary structure-activity-relationships (SAR) and ligand efficiency scores (LE and LLE).
Place, publisher, year, edition, pages
2017. Vol. 27, no 15, p. 3219-3225
Keywords [en]
DCTPP1, Nucleotide metabolism, Pyridone, Pyrimidone
National Category
Chemical Sciences Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:su:diva-145862DOI: 10.1016/j.bmcl.2017.06.039ISI: 000405106500002PubMedID: 28655422OAI: oai:DiVA.org:su-145862DiVA, id: diva2:1135514
Available from: 2017-08-23 Created: 2017-08-23 Last updated: 2022-02-28Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records

Häggblad, MariaMartens, UlfLundgren, Bo

Search in DiVA

By author/editor
Häggblad, MariaMartens, UlfLundgren, Bo
By organisation
Department of Biochemistry and BiophysicsScience for Life Laboratory (SciLifeLab)
In the same journal
Bioorganic & Medicinal Chemistry Letters
Chemical SciencesPharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 94 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.46.0
|
WCAG
|
Stockholm University Library
|
DiVA portal
|
DiVA Contact
|
DiVA Log in