Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Insulin Signaling in the Peripheral and Central Nervous System Regulates Female Sexual Receptivity during Starvation in Drosophila
Stockholm University, Faculty of Science, Department of Zoology, Functional Morphology.ORCID iD: 0000-0002-9190-6873
2017 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 8, 1-9 p., 685Article in journal (Refereed) Published
Abstract [en]

Many animals adjust their reproductive behaviour according to nutritional state and food availability. Drosophila females for instance decrease their sexual receptivity following starvation. Insulin signalling, which regulates many aspects of insect physiology and behaviour, also affects reproduction in females. We show that insulin signalling is involved in the starvation-induced reduction in female receptivity. More specifically, females mutant for the insulin-like peptide 5 (dilp5) were less affected by starvation compared to the other dilp mutants and wild-type flies. Knocking-down the insulin receptor, either in all fruitless-positive neurons or a subset of these neurons dedicated to the perception of a male aphrodisiac pheromone, decreased the effect of starvation on female receptivity. Disrupting insulin signalling in some parts of the brain, including the mushroom bodies even abolished the effect of starvation. In addition, we identified fruitless-positive neurons in the dorso-lateral protocerebrum and in the mushroom bodies co-expressing the insulin receptor. Together, our results suggest that the interaction of insulin peptides determines the tuning of female sexual behaviour, either by acting on pheromone perception or directly in the central nervous system.

Place, publisher, year, edition, pages
2017. Vol. 8, 1-9 p., 685
Keyword [en]
mating behavior, feeding state, insulin, fruitless, mushroom bodies
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-146769DOI: 10.3389/fphys.2017.00685ISI: 000409856700001OAI: oai:DiVA.org:su-146769DiVA: diva2:1139526
Available from: 2017-09-08 Created: 2017-09-08 Last updated: 2017-10-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Carlsson, Mikael A.
By organisation
Functional Morphology
In the same journal
Frontiers in Physiology
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 24 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf