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Integration of mRNP formation and export
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 2
2017 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 74, no 16, 2875-2897 p.Article, review/survey (Refereed) Published
Abstract [en]

Expression of protein-coding genes in eukaryotes relies on the coordinated action of many sophisticated molecular machineries. Transcription produces precursor mRNAs (pre-mRNAs) and the active gene provides an environment in which the pre-mRNAs are processed, folded, and assembled into RNA-protein (RNP) complexes. The dynamic pre-mRNPs incorporate the growing transcript, proteins, and the processing machineries, as well as the specific protein marks left after processing that are essential for export and the cytoplasmic fate of the mRNPs. After release from the gene, the mRNPs move by diffusion within the interchromatin compartment, making up pools of mRNPs. Here, splicing and polyadenylation can be completed and the mRNPs recruit the major export receptor NXF1. Export competent mRNPs interact with the nuclear pore complex, leading to export, concomitant with compositional and conformational changes of the mRNPs. We summarize the integrated nuclear processes involved in the formation and export of mRNPs.

Place, publisher, year, edition, pages
2017. Vol. 74, no 16, 2875-2897 p.
Keyword [en]
Gene expression, Splicing, Polyadenylation, Cell nucleus, Nucleocytoplasmic export, Export receptors, mRNA, Pre-mRNA processing, mRNP assembly, Nuclear pore complex
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-145969DOI: 10.1007/s00018-017-2503-3ISI: 000404961300001OAI: oai:DiVA.org:su-145969DiVA: diva2:1141717
Available from: 2017-09-15 Created: 2017-09-15 Last updated: 2017-09-15Bibliographically approved

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Björk, PetraWieslander, Lars
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