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Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
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Number of Authors: 9
2017 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 107, 82-88 p.Article in journal (Refereed) Published
Abstract [en]

Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13 +/- 4.8 months), including a repeat sample time point for 13 infants (similar to 5 months apart). We observed higher rates of POP quantification in faeces (2 g dry weight) than in plasma (0.5 mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C-f) and blood (C-b) were correlated (r > 0.74, P < 0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3', 4,4', 5-pentachlorobiphenyl (PCB118), 2,2', 3,4,4', 5'-pentachlorobiphenyl (PCB138) and 2,2', 4,4', 5,5'-pentachlorobiphenyl (PCB153). We determined faeces: plasma concentration ratios (K-fb), which can be used to estimate C-b from measurements of C-f for infants/toddlers. For a given chemical, the variation in K-fb across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K-fb over the first year of life. The strong correlations between C-f and C-b demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K-fb could improve the precision and utility of this technique.

Place, publisher, year, edition, pages
2017. Vol. 107, 82-88 p.
Keyword [en]
POPs, Non-invasive bio-monitoring, Infants, Toddlers, Faeces, Blood
National Category
Earth and Related Environmental Sciences
Identifiers
URN: urn:nbn:se:su:diva-146949DOI: 10.1016/j.envint.2017.06.019ISI: 000407490900010PubMedID: 28689110OAI: oai:DiVA.org:su-146949DiVA: diva2:1142469
Available from: 2017-09-19 Created: 2017-09-19 Last updated: 2017-09-19Bibliographically approved

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