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The Amyloid-beta Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. University of Oxford, UK.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. The National Institute of Chemical Physics and Biophysics, Estonia.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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Number of Authors: 5
2017 (English)In: Israel Journal of Chemistry, ISSN 0021-2148, Vol. 57, no 7-8, 674-685 p.Article, review/survey (Refereed) Published
Abstract [en]

This review describes interactions between the amyloid- peptide (A) involved in Alzheimer's disease (AD) and endogenous metal ions and proteins, with an emphasis on future potential drug therapies and targets. AD is characterised by loss of neurons, memory, and cognitive functions, and by formation of cerebral senile plaque deposits. These plaques consist mainly of aggregated A peptides. AD pathology includes a) on the molecular level imbalanced concentrations of A peptides and metal ions, and formation of amyloid structures, and b) on the physiological level a combination of inflammatory responses and oxidative stress effects causing neuronal death. Interestingly, certain blood proteins and metal ions can affect the A amyloid aggregation process. These interactions are the topics of the present review. A deeper understanding of these interactions could facilitate new therapeutic strategies against AD. Previous therapeutic approaches and trials are also briefly described.

Place, publisher, year, edition, pages
2017. Vol. 57, no 7-8, 674-685 p.
Keyword [en]
Alzheimer's disease, amyloid, blood proteins, protein aggregation, transition metals
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-147187DOI: 10.1002/ijch.201600105ISI: 000407253500011OAI: oai:DiVA.org:su-147187DiVA: diva2:1143015
Available from: 2017-09-20 Created: 2017-09-20 Last updated: 2017-09-20Bibliographically approved

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Wallin, CeciliaJarvet, JüriWärmländer, Sebastian K. T. S.Gräslund, Astrid
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