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Insect Antimicrobial Defences: A Brief History, Recent Findings, Biases, and a Way Forward in Evolutionary Studies
Stockholm University, Faculty of Science, Department of Zoology.ORCID iD: 0000-0002-8782-3477
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Zoology.
2017 (English)In: Advances in Insect Physiology, ISSN 0065-2806, E-ISSN 2213-6800, Vol. 52, p. 1-33Article in journal (Refereed) Published
Abstract [en]

We propose that an evolutionary and phenotype-driven approach, harnessing current technological developments, has much to offer for our understanding of insect immunity. After briefly reviewing the history of the discovery of canonical immune system, the current understanding of its components is reviewed and then we argue that the current paradigm of research may be biassed due to (a) its limited taxonomic perspective, (b) the evolutionary time scale being studied, and (c) a focus primarily if not exclusively, upon the canonical, humoural gene set. For the rest of the review, we then discuss the importance of a phenotype down approach as an understudied perspective, exemplified by the need for understanding the basis of cellular responses and wounding as a source of selection on immunity in the wild. We propose that research on those topics almost certainly will provide new insights into the evolution of the insect immune system.

Place, publisher, year, edition, pages
2017. Vol. 52, p. 1-33
Keywords [en]
Wounding, Innate immunity, Evolution, Epistasis, Selection dynamics. Biases, Comparative genomics
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:su:diva-148604DOI: 10.1016/bs.aiip.2017.02.003ISI: 000414265200002OAI: oai:DiVA.org:su-148604DiVA, id: diva2:1153983
Available from: 2017-11-01 Created: 2017-11-01 Last updated: 2017-12-11Bibliographically approved

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Keehnen, Naomi L. P.Theopold, UlrichWheat, Christopher W.
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Department of ZoologyDepartment of Molecular Biosciences, The Wenner-Gren Institute
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