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The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD(3)
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Number of Authors: 11
2017 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 159, 239-248 p.Article in journal (Refereed) Published
Abstract [en]

The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6 h, 24 h and 48 h post-exposure in nine healthy volunteers. Expression of 20 genes was down regulated and one was up-regulated at 6 h after FSSR. All recovered to baseline expression at 24 h or 48 h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D-3 [250HD(3)] levels increased over time after FSSR and were maximal at 48 h. The increase was more pronounced in participants with low basal 250HD(3) levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 250HD(3) and blood cell subpopulations.

Place, publisher, year, edition, pages
2017. Vol. 159, 239-248 p.
Keyword [en]
Solar ultraviolet radiation, Vitamin D, Blood, Gene expression, MiRNA expression
National Category
Earth and Related Environmental Sciences Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:su:diva-148837DOI: 10.1016/j.envres.2017.07.045ISI: 000413280500027PubMedID: 28822308OAI: oai:DiVA.org:su-148837DiVA: diva2:1156572
Available from: 2017-11-13 Created: 2017-11-13 Last updated: 2017-11-13Bibliographically approved

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Kang, WenjingFriedlander, Marc R.
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Department of Molecular Biosciences, The Wenner-Gren InstituteScience for Life Laboratory (SciLifeLab)
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