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Molecularly imprinted polymer-sol-gel tablet toward micro-solid phase extraction: II. Determination of amphetamine in human urine samples by liquid chromatography tandem mass spectrometry
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Number of Authors: 4
2017 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1063, 130-135 p.Article in journal (Refereed) Published
Abstract [en]

Amphetamine selective molecularly imprinted sol-gel polymer tablets, MIP-tablets, for solid-phase micro extraction of biofluid samples were prepared. An acetonitrile solution of deuterated amphetamine template and silane precursor, 3-(propylmethacrylate) trimethoxysilane, was soaked into the pores of polyethylene tablet substrates and polymerized by an acid-catalysed sol-gel process. Application of the resultant MIP-tablets to extract amphetamine from human urine samples followed by LC-MS/MS analysis was investigated. The extraction protocol was optimised with respect to pH of sample, addition of sodium chloride, extraction time, desorption solvent and desorption time. The final analysis method determined amphetamine in human urine with a limit of detection (LOD) of 1.0 ng/mL and a lower limit of quantification (LLOQ) of 5 ng/mL. Validation demonstrated accuracy of the method was 91.0-104.0% and inter-assay precision was 4.8-8.5% (RSD). Extraction recovery was 80%. The MIP-tablets could be re-used and the same tablet could be employed for more than twenty extractions.

Place, publisher, year, edition, pages
2017. Vol. 1063, 130-135 p.
Keyword [en]
Molecularly imprinted polymer, Sol-gel, Tablet, Micro-solid phase extraction, Amphetamine, Urine samples
National Category
Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-148939DOI: 10.1016/j.jchromb.2017.08.027ISI: 000412255000019PubMedID: 28863334OAI: oai:DiVA.org:su-148939DiVA: diva2:1156719
Available from: 2017-11-14 Created: 2017-11-14 Last updated: 2017-11-14Bibliographically approved

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