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Targeting proteins to RNA transcription and processing sites within the nucleus
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 9
2017 (English)In: International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, E-ISSN 1878-5875, Vol. 91, 194-202 p.Article in journal (Refereed) Published
Abstract [en]

Studies of the spatial organization of the highly compartmentalized eukaryotic nucleus and dynamics of transcription and RNA processing within it are fundamental for fully understanding how gene expression is regulated in the cell. Although some progress has been made in deciphering the functional consequences of this complex network of interacting molecules in the context of nuclear organization, how proteins and RNA move in the nucleus and how the transcription and RNA processing machineries find their targets are important questions that remain largely unexplored. Here, we review major hallmarks and novel insights regarding the movement of RNA and proteins in the context of nuclear organization as well as the mechanisms by which the proteins involved in RNA processing localize to specific nuclear compartments.

Place, publisher, year, edition, pages
2017. Vol. 91, 194-202 p.
Keyword [en]
Nuclear organization, Nuclear bodies, Nuclear speckles, Splicing, Targeting signal
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-149035DOI: 10.1016/j.biocel.2017.06.001ISI: 000413879500014PubMedID: 28600144OAI: oai:DiVA.org:su-149035DiVA: diva2:1157969
Conference
1st International Caparica Conference in Splicing (SPLICING), Lisbon, Portugal, September, 12-14, 2016
Available from: 2017-11-17 Created: 2017-11-17 Last updated: 2017-11-17Bibliographically approved

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