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Difference in disorder between eukaryotes and prokaryotes is largely due to Serine in linker regions
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
(English)Manuscript (preprint) (Other academic)
Abstract [en]

In this study we ask what are the molecular properties that make eukaryotic proteins more disordered than prokaryotic ones. First, we show that on average eukaryotic proteins contain more amino acids that are promoting disorder. In particular the fraction of Serine residues is close to 8% of all residues in eukaryotes and less than 6% in prokaryotes. Second, we show that domains unique to eukaryotes and linker regions in eukaryotes are both more disordered and more abundant than corresponding regions in prokaryotic proteins. Serine is an important residue for post-translational modification and regulatory mechanisms. Therefore, we conclude that it is not unlikely that both the need for regulation in a complex eukaryotic cell and the increased amount of longer multi-domain proteins contribute to the higher intrinsic structural disorder in eukaryotic proteins.

National Category
Biological Sciences
Research subject
Biochemistry towards Bioinformatics
Identifiers
URN: urn:nbn:se:su:diva-149167OAI: oai:DiVA.org:su-149167DiVA: diva2:1158355
Available from: 2017-11-20 Created: 2017-11-20 Last updated: 2017-11-20Bibliographically approved
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