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Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 13
2017 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 6, e29156Article in journal (Refereed) Published
Abstract [en]

The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the basis for this lower susceptibility to malaria by the Fulani is unknown. The incidence of classic malaria resistance genes are lower in the Fulani than in other sympatric ethnic populations, and targeted SNP analyses of other candidate genes involved in the immune response to malaria have not been able to account for the observed difference in the Fulani susceptibility to P.falciparum. Therefore, we have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection.

Place, publisher, year, edition, pages
2017. Vol. 6, e29156
National Category
Biological Sciences
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URN: urn:nbn:se:su:diva-148886DOI: 10.7554/eLife.29156ISI: 000412360800001OAI: oai:DiVA.org:su-148886DiVA: diva2:1158991
Available from: 2017-11-21 Created: 2017-11-21 Last updated: 2017-11-29Bibliographically approved

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Quin, Jaclyn E.Bujila, IoanaTroye-Blomberg, MaritaÖstlund Farrants, Ann-Kristin
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