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Probing the relationship between external and internal human exposure of organophosphate flame retardants using pharmacokinetic modelling
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. IVL Swedish Environmental Research Institute, Sweden.
IVL Swedish Environmental Research Institute, Sweden.ORCID iD: 0000-0002-7035-8660
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Number of Authors: 6
2017 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 230, 550-560 p.Article in journal (Refereed) Published
Abstract [en]

Human external exposure (i.e. intake) of organophosphate flame retardants (PFRs) has recently been quantified, but no link has yet been established between external and internal exposure. In this study, we used a pharmacokinetic (PK) model to probe the relationship between external and internal exposure data for three PFRs (EHDPHP, TNBP and TPHP) available for a Norwegian cohort of 61 individuals from 61 different households. Using current literature on metabolism of PFRs,, we predicted the metabolite serum/urine concentrations and compared it to measured data from the study population. Unavailable parameters were estimated using a model fitting approach (least squares method) after assigning reasonable constraints on the ranges of fitted parameters. Results showed an acceptable comparison between PK model estimates and measurements (<10-fold deviation) for EHDPHP. However, a deviation of 10-1000 was observed between PM model estimates and measurements for TNBP and TPHP. Sensitivity and uncertainty analysis on the PK model revealed that EHDPHP results showed higher uncertainty than TNBP or TPHP. However, there are indications that (1) current biomarkers of exposure (i.e. assumed metabolites) for TNBP and TPHP chemicals might not be specific and ultimately affecting the outcome of the modelling and (2) some exposure pathways might be missing. Further research, such as in vivo laboratory metabolism experiments of PFRs including identification of better biomarkers will reduce uncertainties in human exposure assessment.

Place, publisher, year, edition, pages
2017. Vol. 230, 550-560 p.
Keyword [en]
Organophosphate flame retardants, Human exposure, Pharmacokinetic modelling, Metabolism
National Category
Earth and Related Environmental Sciences
Identifiers
URN: urn:nbn:se:su:diva-148976DOI: 10.1016/j.envpol.2017.07.002ISI: 000412250900059PubMedID: 28709054OAI: oai:DiVA.org:su-148976DiVA: diva2:1162810
Available from: 2017-12-05 Created: 2017-12-05 Last updated: 2017-12-05Bibliographically approved

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