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Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Jönköping University, Sweden.
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Number of Authors: 72017 (English)In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 128, no 9, p. 1575-1582Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population.& para;& para;Methods: Patients with Alzheimer's disease (AD, n = 58), mild cognitive impairment (MCI, n = 141), subjective cognitive impairment (SCI, n = 194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording. Background activity (BA) and episodic and continuous abnormalities were assessed visually in EEG.& para;& para;Results: WML (p = 0.006) and atrophy in medial temporal regions (MTA) (p = <0.001) were associated with slower BA in all diagnoses. WML were associated in SCI with total episodic EEG abnormalities (p = 0.03).& para;& para;Conclusions: EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.& para;& para;Significance: Even the standard visually assessed EEG can complement a memory clinic diagnostic workup.

Place, publisher, year, edition, pages
2017. Vol. 128, no 9, p. 1575-1582
Keywords [en]
Electroencephalography, White matter lesions, Medial temporal atrophy, Cognitive impairment, Visual analysis
National Category
Neurology
Identifiers
URN: urn:nbn:se:su:diva-149761DOI: 10.1016/j.clinph.2017.05.018ISI: 000415742000006PubMedID: 28709123OAI: oai:DiVA.org:su-149761DiVA, id: diva2:1164698
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2017-12-11Bibliographically approved

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CiteExportLink to record
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