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Postinfectious olfactory loss: A retrospective study on 791 patients
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics.
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2018 (English)In: The Laryngoscope, ISSN 0023-852X, E-ISSN 1531-4995, Vol. 128, no 1, p. 10-15Article in journal (Refereed) Published
Abstract [en]

Objectives/Hypothesis: Postinfectious olfactory loss is among the most common causes of olfactory impairment and has substantial negative impact on patients' quality of life. Recovery rates have been shown to spontaneously improve in most of patients, usually within 2 to 3 years. However, existing studies are limited by small sample sizes and short follow-up. We aimed to assess the prognostic factors for recovery in a large sample of 791 patients with postinfectious olfactory disorders.

Study Design: Retrospective cohort.

Methods: We performed a retrospective analysis of 791 patients with postinfectious olfactory loss. Olfactory functions were assessed using the Sniffin' Sticks test at the first and final visits (mean follow-up = 1.94 years).

Results: Smell test scores improved over time. In particular, patient's age and the odor threshold (T), odor discrimination (D), and odor identification (I) (TDI) score at first visit were significant predictors of the extent of change. The percentage of anosmic and hyposmic patients exhibiting clinically significant improvement was 46% and 35%, respectively.

Conclusions: This study provides new evidence within the postinfectious olfactory loss literature, shedding light on the prognostic factors and showing that recovery of olfactory function is very frequent, even many years after the infection.

Place, publisher, year, edition, pages
2018. Vol. 128, no 1, p. 10-15
Keywords [en]
postinfectious olfactory loss, recovery, smell disorders, Sniffin' Sticks
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-150686DOI: 10.1002/lary.26606ISI: 000418424600011OAI: oai:DiVA.org:su-150686DiVA, id: diva2:1170162
Note

This research was supported by a grant from the Deutsche Forschungsgemeinschaft to t.h. (DFG HU411/18-1) and the Swedish Foundation for Humanities and Social Sciences to M.L. (M14-0375:1).

Available from: 2018-01-02 Created: 2018-01-02 Last updated: 2018-01-08Bibliographically approved

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