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Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0002-4854-5531
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Umeå University, Sweden.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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2017 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 591, no 22, 3781-3792 p.Article in journal (Refereed) Published
Abstract [en]

Botulinum neurotoxins are highly toxic substances and are all encoded together with one of two alternative gene clusters, the HA or the OrfX gene cluster. Very little is known about the function and structure of the proteins encoded in the OrfX gene cluster, which in addition to the toxin contains five proteins (OrfX1, OrfX2, OrfX3, P47, and NTNH). We here present the structures of OrfX2 and P47, solved to 2.1 and 1.8 Å, respectively. We show that they belong to the TULIP protein superfamily, which are often involved in lipid binding. OrfX1 and OrfX2 were both found to bind phosphatidylinositol lipids.

Place, publisher, year, edition, pages
2017. Vol. 591, no 22, 3781-3792 p.
Keyword [en]
botulinum neurotoxin, Crystallography, gene cluster, TULIP, X-ray
National Category
Structural Biology Biochemistry and Molecular Biology
Research subject
Biochemistry
Identifiers
URN: urn:nbn:se:su:diva-150675DOI: 10.1002/1873-3468.12889ISI: 000416726600008OAI: oai:DiVA.org:su-150675DiVA: diva2:1170198
Funder
Swedish Research Council, 2014-5667Wenner-Gren FoundationsSwedish Cancer Society
Available from: 2018-01-02 Created: 2018-01-02 Last updated: 2018-01-08Bibliographically approved
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