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Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 182017 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 8, article id 1699Article in journal (Refereed) Published
Abstract [en]

The intestinal microbiota influences immune maturation during childhood, and is implicated in early-life allergy development. However, to directly study intestinal microbes and gut immune responses in infants is difficult. To investigate how different types of early-life gut microbiota affect immune development, we collected fecal samples from children with different allergic heredity (AH) and inoculated germ-free mice. Immune responses and microbiota composition were evaluated in the offspring of these mice. Microbial composition in the small intestine, the cecum and the colon were determined by 16S rRNA sequencing. The intestinal microbiota differed markedly between the groups of mice, but only exposure to microbiota associated with AH and known future allergy in children resulted in a T helper 17 (Th17)-signature, both systemically and in the gut mucosa in the mouse offspring. These Th17 responses could be signs of a particular microbiota and a shift in immune development, ultimately resulting in an increased risk of allergy.

Place, publisher, year, edition, pages
2017. Vol. 8, article id 1699
Keywords [en]
infant microbiota, allergic heredity, immune development, germ-free, T helper 17-responsesIN
National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-150873DOI: 10.3389/fimmu.2017.01699ISI: 000416803000001PubMedID: 29250074OAI: oai:DiVA.org:su-150873DiVA, id: diva2:1172650
Available from: 2018-01-10 Created: 2018-01-10 Last updated: 2018-01-10Bibliographically approved

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Nordlander, SofiaQazi, Khaleda RahmanOsman, Omneya AhmedHell, EvaBjörkander, SophiaHaileselassie, YenenehHughes, DiarmaidUdekwu, Klas I.Sverremark-Ekström, Eva
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