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Molecular Alliance of Lymantria dispar Multiple Nucleopolyhedrovirus and a Short Unmodified Antisense Oligonucleotide of Its Anti-Apoptotic IAP-3 Gene: A Novel Approach for Gypsy Moth Control
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Number of Authors: 15
2017 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 18, no 11, 2446Article in journal (Refereed) Published
Abstract [en]

Baculovirus IAP (inhibitor-of-apoptosis) genes originated by capture of host genes. Unmodified short antisense DNA oligonucleotides (oligoDNAs) from baculovirus IAP genes can down-regulate specific gene expression profiles in both baculovirus-free and baculovirus-infected insects. In this study, gypsy moth (Lymantria dispar) larvae infected with multiple nucleopolyhedrovirus (LdMNPV), and LdMNPV-free larvae, were treated with oligoDNA antisense to the RING (really interesting new gene) domain of the LdMNPV IAP-3 gene. The results with respect to insect mortality, biomass accumulation, histological studies, RT-PCR, and analysis of DNA apoptotic fragmentation suggest that oligoRING induced increased apoptotic processes in both LdMNPV-free and LdMNPV-infected insect cells, but were more pronounced in the latter. These data open up possibilities for promising new routes of insect pest control using antisense phosphodiester DNA oligonucleotides.

Place, publisher, year, edition, pages
2017. Vol. 18, no 11, 2446
Keyword [en]
baculovirus infection, gypsy moth Lymantria dispar, multiple nucleopolyhedrovirus IAP (inhibitor-of-apoptosis) genes, RING (really interesting new gene), DNA insecticides, insect pest management
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Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-150995DOI: 10.3390/ijms18112446ISI: 000416811300217OAI: oai:DiVA.org:su-150995DiVA: diva2:1173163
Available from: 2018-01-11 Created: 2018-01-11 Last updated: 2018-01-11Bibliographically approved

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Skorokhod, Oleksii A.
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Department of Molecular Biosciences, The Wenner-Gren Institute
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