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Platelet MAO-B, personality, and psychopathology
Stockholm University, Faculty of Social Sciences, Centre for Health Equity Studies (CHESS). Stockholm University, Faculty of Social Sciences, Department of Psychology, Biological psychology.
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2005 (English)In: Journal of Abnormal Psychology, ISSN 0021-843X, E-ISSN 1939-1846, Vol. 114, no 3, p. 477-482Article in journal (Refereed) Published
Abstract [en]

The article investigates the relationships between platelet monoamine oxidase-B (MAO-B) activity, personality, and psychopathology (Diagnostic and Statistical Manual of Mental Disorders [4th ed.; American Psychiatric Association, 1994] diagnoses. These relationships were assessed in 178 incarcerated male juvenile delinquents. Even after controlling for smoking, the authors found that both Internalizing and Externalizing Psychopathology were negatively related to MAO-B activity. In the final reduced model, novelty seeking fully mediated the relationships between MAO-B and Externalizing Psychopathology but not between MAO-B and Internalizing Psychopathology. It was hypothesized that low platelet MAO-B activity does not directly predispose individuals to psychopathology but is related to specific personality traits, which in turn represent a vulnerability factor for psychopathology. Future studies should help clarify the nature of the relationships between personality, biological markers, and psychopathology.

Place, publisher, year, edition, pages
American Psychological Association (APA), 2005. Vol. 114, no 3, p. 477-482
Keywords [en]
platelet MAO-B, personality, psychopathology
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-152226DOI: 10.1037/0021-843X.114.3.477OAI: oai:DiVA.org:su-152226DiVA, id: diva2:1178351
Available from: 2018-01-29 Created: 2018-01-29 Last updated: 2018-01-29

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