Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Human Scalp Hair as an Indicator of Exposure to the Environmental Toxin -N-Methylamino-l-alanine
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Number of Authors: 42018 (English)In: Toxins, ISSN 2072-6651, E-ISSN 2072-6651, Vol. 10, no 1, article id 14Article in journal (Refereed) Published
Abstract [en]

Dietary or aerosol exposure to the environmental neurotoxin -N-methylamino-l-alanine (BMAA) is a putative risk factor for the development of sporadic neurodegenerative disease. There are many potential sources of BMAA in the environment, but BMAA presence and quantities are highly variable. It has been suggested that BMAA in human hair may serve as an indicator of exposure. We sought to evaluate the use of the BMAA content of human scalp hair as an indicator of exposure, as well as the correlation between specific lifestyle or dietary habits, reported as hypothesised exposure risk factors, and BMAA in hair. Scalp hair samples and questionnaires were collected from participants in a small residential village surrounding a freshwater impoundment renowned for toxic cyanobacterial blooms. Data suggested a positive correlation between hair BMAA content and consumption of shellfish, and possibly pork. No statistically significant correlations were observed between hair BMAA content and residential proximity to the water or any other variable. Hair BMAA content was highly variable, and in terms of exposure, probably reflects primarily dietary exposure. However, the BMAA content of human hair may be affected to a great extent by several other factors, and as such, should be used with caution when evaluating human BMAA exposure, or correlating exposure to neurodegenerative disease incidence.

Place, publisher, year, edition, pages
2018. Vol. 10, no 1, article id 14
Keywords [en]
-N-methylamino-l-alanine, BMAA, exposure, aerosol, diet, hair, bioaccumulation, cyanobacteria
National Category
Environmental Sciences Microbiology Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:su:diva-153873DOI: 10.3390/toxins10010014ISI: 000424096500014OAI: oai:DiVA.org:su-153873DiVA, id: diva2:1188463
Available from: 2018-03-07 Created: 2018-03-07 Last updated: 2018-03-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Search in DiVA

By author/editor
Zguna, Nadezda
By organisation
Department of Environmental Science and Analytical Chemistry
In the same journal
Toxins
Environmental SciencesMicrobiologyOccupational Health and Environmental Health

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 6 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf