Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bacicyclin, a new antibacterial cyclic hexapeptide from Bacillus sp strain BC028 isolated from Mytilus edulis
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. GEOMAR Helmholtz Centre for Ocean Research Kiel, Germany.
Show others and affiliations
Number of Authors: 52018 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 28, no 4, p. 558-561Article in journal (Refereed) Published
Abstract [en]

A new cyclic hexapeptide, cyclo-(Gly-Leu-Val-IIe-Ala-Phe), named bacicyclin (1), was isolated from a marine Bacillus sp. strain associated with Mytilus edulis. The sequences of the amino acid building blocks of the cyclic peptide and its structure were determined by 1D- and 2D-NMR techniques. Marfey's analysis showed that the amino acid building blocks had L-configuration in all cases except for alanine and phenylalanine, which had D-configuration. Bacicyclin (1) exhibited antibacterial activity against the clinically relevant strains Enterococcus faecalis and Staphylococcus aureus with minimal inhibitory concentration values of 8 and 12 mu M, respectively. These results demonstrate the potential of marine bacteria as a promising source for the discovery of new antibiotics.

Place, publisher, year, edition, pages
2018. Vol. 28, no 4, p. 558-561
Keywords [en]
Cyclic peptide, Bacillus sp., Marfey's analysis, Antibacterial activity
National Category
Chemical Sciences Microbiology Microbiology in the medical area
Identifiers
URN: urn:nbn:se:su:diva-154590DOI: 10.1016/j.bmcl.2018.01.062ISI: 000425882800003PubMedID: 29422389OAI: oai:DiVA.org:su-154590DiVA, id: diva2:1195653
Available from: 2018-04-06 Created: 2018-04-06 Last updated: 2018-04-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Motiei, Asa
By organisation
Department of Environmental Science and Analytical Chemistry
In the same journal
Bioorganic & Medicinal Chemistry Letters
Chemical SciencesMicrobiologyMicrobiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf