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Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma cell survival niche, memory B-cells and gut microbiota in vaccine responses
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-6271-8681
Number of Authors: 42018 (English)In: Blood reviews, ISSN 0268-960X, E-ISSN 1532-1681, Vol. 32, no 1, p. 71-80Article, review/survey (Refereed) Published
Abstract [en]

Acute lymphoblastic leukaemia (ALL) is the most common type of cancer in children, accounting for approximately 25% of childhood cancer cases. As a result of effective treatments over the past decades, paediatric ALL mortality has been greatly reduced. Chemotherapy, however, has a range of harmful side effects including the loss of protective antibodies against vaccine-preventable diseases. Since ALL survivors have an increased risk of health problems including organ insufficiencies, acquired vaccine-preventable infections subsequent to clinical remission could become life threatening to these individuals. This review will summarize clinical findings regarding defective humoral immunity in ALL survivors, identify current knowledge gaps and highlight mechanisms related to deficiencies in the B-cell compartment important for serological memory. Further, we illuminate the emerging evidence for a relationship between chemotherapy and gut microbiota, which could play an important role in vaccine responses and the shaping of a young immune system subjected to maturation and recovery.

Place, publisher, year, edition, pages
2018. Vol. 32, no 1, p. 71-80
Keywords [en]
Acute lymphoblastic leukaemia survivors, Serological memory, Plasma cell niche, Bone-marrow stromal cells, Memory B-cells, Gut microbiota, Childhood vaccines
National Category
Hematology Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-154663DOI: 10.1016/j.blre.2017.08.009ISI: 000427100200007PubMedID: 28886882OAI: oai:DiVA.org:su-154663DiVA, id: diva2:1201986
Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2018-04-27Bibliographically approved

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