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Estimation of Risk of Normal-tissue Toxicity Following Gastric Cancer Radiotherapy with Photon- or Scanned Proton-beams
Stockholm University, Faculty of Science, Department of Physics. Eduardo Mondlane University, Mozambique .ORCID iD: 0000-0002-9904-7217
Stockholm University, Faculty of Science, Department of Physics.
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2018 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 38, no 5, p. 2619-2625Article in journal (Refereed) Published
Abstract [en]

Background/Aim: Gastric cancer (GC) radiotherapy involves irradiation of large tumour volumes located in the proximities of critical structures. The advantageous dose distributions produced by scanned-proton beams could reduce the irradiated volumes of the organs at risk (OARs). However, treatment-induced side-effects may still appear. The aim of this study was to estimate the normal tissue complication probability (NTCP) following proton therapy of GC, compared to photon radiotherapy. Patients and Methods: Eight GC patients, previously treated with volumetric-modulated arc therapy (VMAT), were retrospectively planned with scanned proton beams carried out with the single-field uniform-dose (SFUD) method. A beam-specific planning target volume was used for spot positioning and a clinical target volume (CTV) based robust optimisation was performed considering setup- and range-uncertainties. The dosimetric and NTCP values obtained with the VMAT and SFUD plans were compared. Results: With SFUD, lower or similar dose-volume values were obtained for OARs, compared to VMAT. NTCP values of 0% were determined with the VMAT and SFUD plans for all OARs (p>0.05), except for the left kidney (p<0.05), for which lower toxicity was estimated with SFUD. Conclusion: The NTCP reduction, determined for the left kidney with SFUD, can be of clinical relevance for preserving renal function after radiotherapy of GC.

Place, publisher, year, edition, pages
2018. Vol. 38, no 5, p. 2619-2625
Keywords [en]
NTCP, gastric cancer, VMAT, SFUD, treatment planning
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Other Physics Topics
Research subject
Medical Radiation Physics
Identifiers
URN: urn:nbn:se:su:diva-156412DOI: 10.21873/anticanres.12503OAI: oai:DiVA.org:su-156412DiVA, id: diva2:1206733
Available from: 2018-05-17 Created: 2018-05-17 Last updated: 2018-05-18Bibliographically approved

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