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Deriving in Vivo Bioconcentration Factors of a Mixture of Fragrance Ingredients Using a Single Dietary Exposure and Internal Benchmarking
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. South China Normal University, China.ORCID iD: 0000-0002-2069-4076
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.ORCID iD: 0000-0001-9159-6652
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Number of Authors: 52018 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 52, no 9, p. 5227-5235Article in journal (Refereed) Published
Abstract [en]

Chemicals in mixtures that are hydrophobic with Log K-OW > 4 are potentially bioaccumulative. Here, we evaluate an abbreviated and benchmarked in vivo BCF measurement methodology by exposing rainbow trout to a mixture of eight test chemicals found in fragrance substances and three benchmark chemicals (musk xylene (MX), hexachlorobenzene (HCB) and PCB52) via a single contaminated feeding event followed by a 28-day depuration period. Concentrations of HCB and PCB52 in fish did not decline significantly (their apparent depuration rate constants, k(T), were close to zero), whereas k(T) for MX was 0.022 d(-1). The test chemicals were eliminated much more rapidly than the benchmark chemicals (k(T) > 0.117 d(-1)). The bioconcentration factors (BCFA) for the test chemicals were in the range of 273 L kg(-1) (8-cyclohexadecen-1-one (globanone)) to 1183 L kg(-1) (alpha-pinene); the benchmarked BCFs (BCFG) calculated relative to HCB ranged from 238 L kg(-1) (globanone) to 1147 L kg(-1) (alpha-pinene). BCFG were not significantly different from BCFA but had smaller standard errors. BCFs derived here agreed well with values previously measured using the OECD 305 test protocol. We conclude that it will be feasible to derive BCFs of chemicals in mixtures using a single dietary exposure and chemical benchmarking.

Place, publisher, year, edition, pages
2018. Vol. 52, no 9, p. 5227-5235
National Category
Environmental Engineering Earth and Related Environmental Sciences
Identifiers
URN: urn:nbn:se:su:diva-156610DOI: 10.1021/acs.est.8b00144ISI: 000431466500022PubMedID: 29605991OAI: oai:DiVA.org:su-156610DiVA, id: diva2:1210433
Available from: 2018-05-28 Created: 2018-05-28 Last updated: 2018-05-28Bibliographically approved

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