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[F-18]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry. AstraZeneca PET Centre at Karolinska Institutet, Sweden.ORCID iD: 0000-0002-1333-7740
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0002-8834-9834
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Number of Authors: 72018 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 54, no 34, p. 4286-4289Article in journal (Refereed) Published
Abstract [en]

Operationally simple radiosynthesis and purification of [F-18]fluoro-benziodoxole was developed starting from a cyclotron produced [F-18]F- precursor, [F-18]TBAF, and tosyl-benziodoxole. The synthetic utility of [F-18]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50-90%) and high molar activity (up to 396 GBq mol(-1)).

Place, publisher, year, edition, pages
2018. Vol. 54, no 34, p. 4286-4289
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Chemical Sciences
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URN: urn:nbn:se:su:diva-156663DOI: 10.1039/c8cc00526eISI: 000430935200013PubMedID: 29632936OAI: oai:DiVA.org:su-156663DiVA, id: diva2:1213159
Available from: 2018-06-04 Created: 2018-06-04 Last updated: 2018-06-04Bibliographically approved

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Cortés González, Miguel A.Bermejo Gómez, AntonioMeyer, Denise N.Szabó, Kálmán J.
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