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Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 142018 (English)In: Cell Metabolism, ISSN 1550-4131, E-ISSN 1932-7420, Vol. 27, no 6, p. 1309-1322.e6Article in journal (Refereed) Published
Abstract [en]

Cellular proteostasis ismaintained via the coordinated synthesis, maintenance, and breakdown of proteins in the cytosol and organelles. While biogenesis of the mitochondrial membrane complexes that execute oxidative phosphorylation depends on cytoplasmic translation, it is unknown how translation within mitochondria impacts cytoplasmic proteostasis and nuclear gene expression. Here we have analyzed the effects of mutations in the highly conserved accuracy center of the yeast mitoribosome. Decreased accuracy of mitochondrial translation shortened chronological lifespan, impaired management of cytosolic protein aggregates, and elicited a general transcriptional stress response. In striking contrast, increased accuracy extended lifespan, improved cytosolic aggregate clearance, and suppressed a normally stress-induced, Msn2/4-dependent interor-ganellar proteostasis transcription program (IPTP) that regulates genes important for mitochondrial proteostasis. Collectively, the data demonstrate that cytosolic protein homeostasis and nuclear stress signaling are controlled by mitochondrial translation efficiency in an inter-connected organelle quality control network that determines cellular lifespan.

Place, publisher, year, edition, pages
2018. Vol. 27, no 6, p. 1309-1322.e6
National Category
Biological Sciences
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URN: urn:nbn:se:su:diva-157770DOI: 10.1016/j.cmet.2018.04.011ISI: 000434480000016PubMedID: 29754951OAI: oai:DiVA.org:su-157770DiVA, id: diva2:1223316
Available from: 2018-06-25 Created: 2018-06-25 Last updated: 2018-06-25Bibliographically approved

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Suhm, TamaraKaimal, Jayasankar MohanakrishnanDawitz, HannahPeselj, CarlottaMasser, Anna E.Smialowska, AgataBjörck, Markus L.Brzezinski, PeterBüttner, SabrinaAndréasson, ClaesOtt, Martin
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Department of Biochemistry and BiophysicsDepartment of Molecular Biosciences, The Wenner-Gren InstituteScience for Life Laboratory (SciLifeLab)
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