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Metals and Parkinson's Disease: Mechanisms and Biochemical Processes
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 62018 (English)In: Current Medicinal Chemistry, ISSN 0929-8673, E-ISSN 1875-533X, Vol. 25, no 19, p. 2198-2214Article, review/survey (Refereed) Published
Abstract [en]

Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.

Place, publisher, year, edition, pages
2018. Vol. 25, no 19, p. 2198-2214
Keywords [en]
Substantia nigra, alpha-synuclein, beta-amyloid, glutamate, glutathione, oxidative stress, metals, dopamine
National Category
Biological Sciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medicinal Chemistry
Identifiers
URN: urn:nbn:se:su:diva-157752DOI: 10.2174/0929867325666171129124616ISI: 000433627700002PubMedID: 29189118OAI: oai:DiVA.org:su-157752DiVA, id: diva2:1223842
Available from: 2018-06-26 Created: 2018-06-26 Last updated: 2018-06-26Bibliographically approved

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Current Medicinal Chemistry
Biological SciencesMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Medicinal Chemistry

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