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Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease
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Number of Authors: 112018 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 14, no 5, p. 652-663Article in journal (Refereed) Published
Abstract [en]

Introduction: Cross-sectional findings using the tau tracer [F-18] THK5317 (THK5317) have shown that [F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early-frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single PET study can provide both functional and molecular information. Methods: We included 16 patients with Alzheimer's disease who completed follow-up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed-effects models and annual percentage change maps were used to examine longitudinal change. Results: Limited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317. Discussion: Our findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity.

Place, publisher, year, edition, pages
2018. Vol. 14, no 5, p. 652-663
Keywords [en]
Positron emission tomography (PET), Tau imaging, THK5317, Neurofibrillary tangles, FDG, Hypometabolism, Perfusion imaging, R-1, Perfusion SUVR, Alzheimer's disease, Prodromal Alzheimer's disease, Alzheimer's disease dementia, Mild cognitive impairment, Longitudinal study
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Neurology Geriatrics
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URN: urn:nbn:se:su:diva-157809DOI: 10.1016/j.jalz.2017.11.008ISI: 000432438800009PubMedID: 29268078OAI: oai:DiVA.org:su-157809DiVA, id: diva2:1234444
Available from: 2018-07-24 Created: 2018-07-24 Last updated: 2018-07-24Bibliographically approved

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