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A study of the interaction between H-pylori mice passage strains and gastric epithelial cells
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
Number of Authors: 42018 (English)In: Pakistan Journal of Pharmaceutical Sciences, ISSN 1011-601X, Vol. 31, no 3, p. 769-775Article in journal (Refereed) Published
Abstract [en]

Helicobacter pylon (H. pylori) infections are very serious health problem that are further worsened by increasing/developing resistance to the current antibiotics. Therefore, new therapeutic agents are needed for H. pylori eradication. Use of a CD46 derived peptide (P3) as bactericidal agent against H. pylon has shown high activity rate in vivo and this study examines the changes in H. pylori features in response to effect of P3 treatment. AGS cells were infected with H. pylon wild type strain 67:21 and its mice passage strains (P3 treated and untreated strains) and further examined using immunoblotting assay, FACS and Urease activity analysis. Comparatively we found increased level of Urease alpha subunit A (UreA) and alkyl hydroperoxide reductase C (AhpC) proteins for P3 treated strain of H. pylori than its wild type or untreated strain after infection of AGS cells. Conclusion These results suggest that there might be a high rate of adherence to host cells for the P3 treated passage strain than untreated or wild type strain. Our findings also indicate that either adhesins are being changed or H pylon interaction to the host cells is affected after P3 treatment.

Place, publisher, year, edition, pages
2018. Vol. 31, no 3, p. 769-775
Keywords [en]
H. pylori, CD46 derived peptide (P3), bactericidal, AGS cells
National Category
Pharmaceutical Sciences Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-157805ISI: 000433275300006PubMedID: 29716854OAI: oai:DiVA.org:su-157805DiVA, id: diva2:1236110
Available from: 2018-07-31 Created: 2018-07-31 Last updated: 2018-07-31Bibliographically approved

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