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Amyloid-beta 1-40 is associated with alterations in NG2+pericyte population exvivo and invitro
Stockholm University, Faculty of Science, Department of Neurochemistry.
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Number of Authors: 72018 (English)In: Aging Cell, ISSN 1474-9718, E-ISSN 1474-9726, Vol. 17, no 3, article id e12728Article in journal (Refereed) Published
Abstract [en]

The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amyloid-beta (A beta) has been suggested as a potential culprit. In the current study, we show reduced number of hippocampal NG2+ pericytes and an association between NG2+ pericyte numbers and A1-40 levels in AD patients. We further demonstrate, using invitro studies, an aggregation-dependent impact of A beta 1-40 on human NG2+ pericytes. Fibril-EP A beta 1-40 exposure reduced pericyte viability and proliferation and increased caspase 3/7 activity. Monomer A beta 1-40 had quite the opposite effect: increased pericyte viability and proliferation and reduced caspase 3/7 activity. Oligomer-EP A beta 1-40 had no impact on either of the cellular events. Our findings add to the growing number of studies suggesting a significant impact on pericytes in the brains of AD patients and suggest different aggregation forms of A beta 1-40 as potential key regulators of the brain pericyte population size.

Place, publisher, year, edition, pages
2018. Vol. 17, no 3, article id e12728
Keywords [en]
Alzheimer's disease, amyloid-beta 1-40, hippocampus, pericytes
National Category
Biological Sciences Rheumatology and Autoimmunity Neurology
Identifiers
URN: urn:nbn:se:su:diva-157711DOI: 10.1111/acel.12728ISI: 000431962300002PubMedID: 29453790OAI: oai:DiVA.org:su-157711DiVA, id: diva2:1236207
Available from: 2018-08-01 Created: 2018-08-01 Last updated: 2018-08-01Bibliographically approved

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Moussaud, SimonNielsen, Henrietta M.
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