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Job strain and atrial fibrillation - Results from the Swedish Longitudinal Occupational Survey of Health and meta-analysis of three studies
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Jönköping University, Sweden.ORCID iD: 0000-0001-9042-4832
Stockholm University, Faculty of Social Sciences, Stress Research Institute.ORCID iD: 0000-0002-2908-1903
Stockholm University, Faculty of Social Sciences, Stress Research Institute.
Number of Authors: 42018 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 25, no 11, p. 1142-1149Article in journal (Refereed) Published
Abstract [en]

Background Knowledge about the impact of occupational exposures, such as work stress, on the risk of atrial fibrillation is limited. The present study aims to investigate the association between job strain, a measure of work stress, and atrial fibrillation.

Design Prospective cohort study design and fixed-effect meta-analysis.

Methods Data from the Swedish Longitudinal Occupational Survey of Health (SLOSH) was utilised for the main analysis, combining self-reported data on work stress at baseline with follow-up data on atrial fibrillation from nationwide registers. Cox proportional hazard regression analyses were used to estimate hazard ratios and 95% confidence intervals (CIs). A fixed-effect meta-analysis was conducted to pool the results from the present study with results from two similar previously published studies.

Results Based on SLOSH data, job strain was associated with an almost 50% increased risk of atrial fibrillation (hazard ratio 1.48, 95% CI 1.00-2.18) after adjustment for age, sex and education. Further adjustment for smoking, physical activity, body mass index and hypertension did not alter the estimated risk. The meta-analysis of the present and two previously published studies showed a consistent pattern, with job strain being associated with increased risk of atrial fibrillation in all three studies. The estimated pooled hazard ratio was 1.37 (95% CI 1.13-1.67).

Conclusion The results highlight that occupational exposures, such as work stress, may be important risk factors for incident atrial fibrillation.

Place, publisher, year, edition, pages
2018. Vol. 25, no 11, p. 1142-1149
Keywords [en]
Atrial fibrillation, work, stress, psychological, risk factors, cohort study
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:su:diva-159134DOI: 10.1177/2047487318777387ISI: 000439593500006PubMedID: 29846118OAI: oai:DiVA.org:su-159134DiVA, id: diva2:1243015
Available from: 2018-08-30 Created: 2018-08-30 Last updated: 2019-12-09Bibliographically approved

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