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Accounting for Two Forms of Hypoxia for Predicting Tumour Control Probability in Radiotherapy: An In Silico Study
Stockholm University, Faculty of Science, Department of Physics.
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institutet, Sweden.ORCID iD: 0000-0002-7101-240X
2018 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 1042, p. 183-187Article in journal (Refereed) Published
Abstract [en]

The progress in functional imaging and dose delivery has opened the possibility of targeting tumour hypoxia with radiotherapy. Advanced approaches apply quantitative information on tumour oxygenation retrieved from imaging in dose prescription. These do not, however, take into account the potential difference in radiosensitivity of chronically and acutely hypoxic cells. It was the aim of this study to evaluate the implications of assuming the same or different sensitivities for the hypoxic cells. An in silico 3D-model of a hypoxic tumour with heterogeneous oxygenation was used to model the probabilities of tumour control with different radiotherapy regimens. The results show that by taking into account the potential lower radioresistance of chronically hypoxic cells deprived of oxygen and nutrients, the total dose required to achieve a certain level of control is substantially reduced for a given fractionation scheme in comparison to the case when chronically and acutely hypoxic cells are assumed to have similar features. The results also suggest that the presence of chronic hypoxia could explain the success of radiotherapy for some hypoxic tumours. Given the implications for clinical dose escalation trials, further exploration of the influence of the different forms of hypoxia on treatment outcome is therefore warranted.

Place, publisher, year, edition, pages
2018. Vol. 1042, p. 183-187
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:su:diva-160429DOI: 10.1007/978-3-319-91287-5_29ISI: 000454396400030PubMedID: 30178343OAI: oai:DiVA.org:su-160429DiVA, id: diva2:1250469
Conference
45th Annual Meeting of the International-Society-on-Oxygen-Transport-to-Tissue (ISOTT), Halle, Germany, August 19-23, 2017
Note

ISBN: 978-3-319-91287-5; 978-3-319-91285-1

Available from: 2018-09-24 Created: 2018-09-24 Last updated: 2019-02-04Bibliographically approved

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