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Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
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Number of Authors: 132018 (English)In: Developmental Cell, ISSN 1534-5807, E-ISSN 1878-1551, Vol. 46, no 4, p. 504-517Article in journal (Refereed) Published
Abstract [en]

Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.

Place, publisher, year, edition, pages
2018. Vol. 46, no 4, p. 504-517
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-160092DOI: 10.1016/j.devcel.2018.07.005ISI: 000442143300010PubMedID: 30078729OAI: oai:DiVA.org:su-160092DiVA, id: diva2:1251088
Available from: 2018-09-26 Created: 2018-09-26 Last updated: 2018-09-26Bibliographically approved

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Giacomello, Stefania
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Department of Biochemistry and BiophysicsScience for Life Laboratory (SciLifeLab)
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