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Small membrane proteins - elucidating the function of the needle in the haystack
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0001-5125-2740
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Number of Authors: 22014 (English)In: Biological chemistry (Print), ISSN 1431-6730, E-ISSN 1437-4315, Vol. 395, no 12, p. 1365-1377Article, review/survey (Refereed) Published
Abstract [en]

Membrane proteins are important mediators between the cell and its environment or between different compartments within a cell. However, much less is known about the structure and function of membrane proteins compared to water-soluble proteins. Moreover, until recently a subset of membrane proteins, those shorter than 100 amino acids, have almost completely evaded detection as a result of technical difficulties. These small membrane proteins (SMPs) have been underrepresented in most genomic and proteomic screens of both pro-and eukaryotic cells and, hence, we know much less about their functions in both. Currently, through a combination of bioinformatics, ribosome profiling, and more sensitive proteomics, large numbers of SMPs are being identified and characterized. Herein we describe recent advances in identifying SMPs from genomic and proteomic datasets and describe examples where SMPs have been successfully characterized biochemically. Finally we give an overview of identified functions of SMPs and speculate on the possible roles SMPs play in the cell.

Place, publisher, year, edition, pages
2014. Vol. 395, no 12, p. 1365-1377
Keywords [en]
AcrZ, KdpF, phospholamban, sORF, transmembrane
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-160569DOI: 10.1515/hsz-2014-0213ISI: 000345024400002PubMedID: 25153378OAI: oai:DiVA.org:su-160569DiVA, id: diva2:1253072
Available from: 2018-10-03 Created: 2018-10-03 Last updated: 2018-10-03Bibliographically approved

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