Although creative industries and creative talent have traditionally clustered in established global centres such as London and New York, new forms of independent production, digital technologies and mobilities are reshaping this landscape. Drawing on 87 interviews and participant observation, this paper considers whether independent fashion designers in Canada still need to locate in the established centres to realize their ambitions. It explores how these entrepreneurs choose a ‘home base’ for their operations and demonstrates how they mobilize three forms of mobility (temporary, mediated, virtual) to access opportunities and resources within Canada’s fashion system.