Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. Masaryk Universit, Czech Republic.
Show others and affiliations
Number of Authors: 142018 (English)In: Europace, ISSN 1099-5129, E-ISSN 1532-2092, Vol. 20, no 9, p. e140-e147Article in journal (Refereed) Published
Abstract [en]

Aims

To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden.

Methods and results

The cohort consisted of 20 men and 4 women (mean age: 62.3 +/- 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 +/- 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008).

Conclusion

Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.

Place, publisher, year, edition, pages
2018. Vol. 20, no 9, p. e140-e147
Keywords [en]
Pacemaker, Implantable cardioverter-defibrillator, Late complication, Metal pollutants, Delayed-type hypersensitivity, Lymphocyte transformation test
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:su:diva-161123DOI: 10.1093/europace/eux227ISI: 000444551400003PubMedID: 29016950OAI: oai:DiVA.org:su-161123DiVA, id: diva2:1259390
Available from: 2018-10-29 Created: 2018-10-29 Last updated: 2018-10-29Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Manousek, JanKuta, JanKlanova, Jana
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Europace
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 36 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf