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Biogenesis of the bc(1) Complex of the Mitochondria! Respiratory Chain
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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Number of Authors: 52018 (English)In: Journal of Molecular Biology, ISSN 0022-2836, E-ISSN 1089-8638, Vol. 430, no 21, p. 3892-3905Article, review/survey (Refereed) Published
Abstract [en]

The oxidative phosphorylation system contains four respiratory chain complexes that connect the transport of electrons to oxygen with the establishment of an electrochemical gradient over the inner membrane for ATP synthesis. Due to the dual genetic source of the respiratory chain subunits, its assembly requires a tight coordination between nuclear and mitochondrial gene expression machineries. In addition, dedicated assembly factors support the step-by-step addition of catalytic and accessory subunits as well as the acquisition of redox cofactors. Studies in yeast have revealed the basic principles underlying the assembly pathways. In this review, we summarize work on the biogenesis of the bc(1) complex or complex III, a central component of the mitochondrial energy conversion system.

Place, publisher, year, edition, pages
2018. Vol. 430, no 21, p. 3892-3905
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:su:diva-161925DOI: 10.1016/j.jmb.2018.04.036ISI: 000448493400002PubMedID: 29733856OAI: oai:DiVA.org:su-161925DiVA, id: diva2:1262800
Available from: 2018-11-13 Created: 2018-11-13 Last updated: 2018-11-13Bibliographically approved

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Ndi, MamaSalvatori, RogerSingh, Abeer PrakashOtt, Martin
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