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Computational models and tools
Stockholm University, Faculty of Science, Department of Physics.ORCID iD: 0000-0002-4160-1078
2018 (English)In: Medical physics, ISSN 0094-2405, Vol. 45, no 11, p. e1073-e1085Article in journal (Refereed) Published
Abstract [en]

In this chapter, we describe two different methods, analytical (pencil beam) algorithms and Monte Carlo simulations, used to obtain the intended dose distributions in patients and evaluate their strengths and shortcomings. We discuss the difference between the prescribed physical dose and the biologically effective dose, the relative biological effectiveness (RBE) between ions and photons and the dependence of RBE on the linear energy transfer (LET). Lastly, we show how LET- or RBE-based optimization can be used to improve treatment plans and explore how the availability of multimodality ion beam facilities can be used to design a tumor-specific optimal treatment.

Place, publisher, year, edition, pages
2018. Vol. 45, no 11, p. e1073-e1085
Keywords [en]
dose calculation, LET, monte carlo, particle therapy, RBE
National Category
Other Physics Topics
Research subject
Medical Radiation Physics
Identifiers
URN: urn:nbn:se:su:diva-162541DOI: 10.1002/mp.12521ISI: 000449995900010PubMedID: 30421814OAI: oai:DiVA.org:su-162541DiVA, id: diva2:1267154
Available from: 2018-11-30 Created: 2018-11-30 Last updated: 2018-12-10Bibliographically approved

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