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Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 162018 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 28, no 11, p. 3894-3907Article in journal (Refereed) Published
Abstract [en]

Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with C-11-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.

Place, publisher, year, edition, pages
2018. Vol. 28, no 11, p. 3894-3907
Keywords [en]
Cognitive Performance, dopamine D-2/3 Receptor Availability, Heterogeneity, Latent Profile Analysis, Older Adults, Working Memory
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:su:diva-163001DOI: 10.1093/cercor/bhx253ISI: 000449432200011PubMedID: 29028935OAI: oai:DiVA.org:su-163001DiVA, id: diva2:1270167
Available from: 2018-12-12 Created: 2018-12-12 Last updated: 2018-12-12Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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