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Sorting mRNA Molecules for Cytoplasmic Transport and Localization
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. New York University Abu Dhabi, United Arab Emirates.
Number of Authors: 22018 (English)In: Frontiers in Genetics, ISSN 1664-8021, E-ISSN 1664-8021, Vol. 9, article id 510Article, review/survey (Refereed) Published
Abstract [en]

In eukaryotic cells, gene expression is highly regulated at many layers. Nascent RNA molecules are assembled into ribonucleoprotein complexes that are then released into the nucleoplasmic milieu and transferred to the nuclear pore complex for nuclear export. RNAs are then either translated or transported to the cellular periphery. Emerging evidence indicates that RNA-binding proteins play an essential role throughout RNA biogenesis, from the gene to polyribosomes. However, the sorting mechanisms that regulate whether an RNA molecule is immediately translated or sent to specialized locations for translation are unclear. This question is highly relevant during development and differentiation when cells acquire a specific identity. Here, we focus on the RNA-binding properties of heterogeneous nuclear ribonucleoproteins (hnRNPs) and how these mechanisms are believed to play an essential role in RNA trafficking in polarized cells. Further, by focusing on the specific hnRNP protein CBF-A/hnRNPab and its naturally occurring isoforms, we propose a model on how hnRNP proteins are capable of regulating gene expression both spatially and temporally throughout the RNA biogenesis pathway, impacting both healthy and diseased cells.

Place, publisher, year, edition, pages
2018. Vol. 9, article id 510
Keywords [en]
mRNA transport and localization, hnRNP proteins, protein-RNA binding, G4 quadruplex, oligodendrocytes, neurons, spermatogenic cells
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-162871DOI: 10.3389/fgene.2018.00510ISI: 000449248600001PubMedID: 30459808OAI: oai:DiVA.org:su-162871DiVA, id: diva2:1274161
Available from: 2018-12-28 Created: 2018-12-28 Last updated: 2018-12-28Bibliographically approved

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Percipalle, Piergiorgio
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